Outcomes of functional substrate mapping of ventricular tachycardia (Func-VT) - an international propensity-matched prospective registry

Abstract Funding Acknowledgements Type of funding sources: None. Background Dynamic substrate changes play a key role in facilitating conduction delay and re-entry ventricular tachycardia (VT) circuits. Extrastimuli pacing can unmask functional channels demonstrated by dynamic delay, which may the VT circuit. We have previously developed sense protocol mapping, using short coupled single extrastimuli to delineate areas maladaptive an essential part development. Purpose conducted multicentre prospective propensity-matched registry mapping (Func-VT registry) compared with conventional mapping. Procedure times, mortality, probability ATP/ICD shocks were matched institutional cohort. Methods Data prospectively analysed from international patients undergoing ablation for Ventricular tachycardia. was gathered multiple sites evaluating outcomes comparing results cohort methods entrainment, activation late potential pace The date age left ejection fraction. Results There 41 (mean 60 years, 80% males, mean fraction: 35%) func-VT registry. median procedure time 161 minutes 305 (p=<0.001). 85% free symptomatic VT/ anti-tachycardia or ICD at follow-up 340 days. Mean per-patient burden decreased 3.5 0.08 same period (p=0.03). Figure 1 shows survival curves demonstrating death Funct-VT vs (p=0.011). Conclusions provides real-world data regarding acute long-term complications. It better improved who underwent